I can think of several ways you can repair neoprene boots, but luckily Xtratuf’s very rarely ever require any repair. That being said, the question of how to repair your boots can only be answered by someone who has places their boots in dangerous situations and come out the other side. Lucky for you I have put a couple holes in a few pair over the years and as a result developed a few strategies for patching up Xtratuf boots.
Four Ways to Repair XtraTuf Boots
Strategy Number One
Gorilla Glue! By far some of the best glue I have ever used for shoe repair. Gorilla glue can patch a hole without much consideration to the size. If it is a small hole it will easily repair it, 
medium sizes just put multiple layers (let each layer dry in between), if it is a large hole combine repair step #3 with Gorilla glue. For the large hole put Gorilla glue around the hole, then place the patch over top, then place more glue around the seem. The key is once it dries, then place another coat around the outside of the seam and then also inside your boot along the seam. The combination will lead you to the promise land and dry feet. Note: It will take a couple wears for the rough spot to wear down on the inside of the boot. Make sure you do not patch and then plan on a long hike, I know this from experience.
Strategy Number Two
Duck Tape! Very often when I put a hole in my boots it happens in the most inopportune places, and the least predictable times. The one thing I always have handy is a role of gray 
duck tape which is sure to get me through the rest of the adventure with dry feet. Basically I put on my boots, and then tape them as tightly as possible across the hole, that is assuming the hole is in the foot. If the hole is in the vertical part of the boot I will often line the inside of my boot with a few sheets of newspaper and then tape tightly enough that I can just barely pull out the newspaper. The newspaper gives me something solid to push/tape against but when I pull it out I still have flexibility in my boot.
Strategy Number Three
Two Words Again – Les Schwab! One time I got my foot caught on a barb wire fence in the middle of the night (don’t ask). I made it back to my buddies house, and slept off the liquid motivation that found me jumping the fence to 
begin with. Needless to say, my boots had a whole in them, luckily for me my buddy worked at a Les Schwab store in town and told me to come by later that day. When I brought my boots by he was able to quickly treat them just like a regular tire with a hole. About 10 minutes I was in and out. Anyway, I am sure you will get some stares when you take in your boots, but at the end of the day Les Schwab is willing to help the craziest amongst us!
Strategy Number Four
I am out of two word expressions so I will leave it to a multi-word phrase and say get yourself a good old bike tire repair kit. Just follow the directions and patch that sucker up. It will not last as long as some other repairs, but it is affordable and you do not have to get others involved like option #2.
If you do not like any of the options above you can always take your boots to a local shoe repair shop. The cost ranges from $40 -$100 depending on the size of the hole, your geographic region and the overall temperament of the repair technician.